Co-administration of ultra-low dose naloxone attenuates morphine tolerance in rats via attenuation of NMDA receptor neurotransmission and suppression of neuroinflammation in the spinal cords. [electronic resource]
Producer: 20100930Description: 236-45 p. digitalISSN:- 1873-5177
- Amino Acid Transport System X-AG -- metabolism
- Analgesics -- administration & dosage
- Animals
- Aspartic Acid -- cerebrospinal fluid
- Drug Interactions
- Drug Tolerance
- Excitatory Amino Acid Transporter 2 -- metabolism
- Excitatory Amino Acid Transporter 3 -- metabolism
- Gene Expression Regulation -- drug effects
- Glutamic Acid -- cerebrospinal fluid
- Injections, Spinal
- Male
- Morphine -- administration & dosage
- Naloxone -- administration & dosage
- Neuroglia -- drug effects
- Phosphorylation -- drug effects
- Protein Kinase C -- metabolism
- Rats
- Rats, Wistar
- Receptors, N-Methyl-D-Aspartate -- antagonists & inhibitors
- Spinal Cord -- drug effects
- Synaptic Transmission -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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