Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) activity in PARP-1 silenced tumour cells increases chemosensitivity to temozolomide and to a N3-adenine selective methylating agent. [electronic resource]
Producer: 20100805Description: 368-83 p. digitalISSN:- 1873-5576
- Animals
- Antineoplastic Agents -- pharmacology
- Blotting, Western
- Cell Division -- drug effects
- Cell Line, Tumor
- Dacarbazine -- analogs & derivatives
- Drug Synergism
- Enzyme Inhibitors -- pharmacology
- Flow Cytometry
- G2 Phase -- drug effects
- HeLa Cells
- Humans
- Melanoma, Experimental -- pathology
- Methylation
- Mice
- Netropsin -- analogs & derivatives
- Poly(ADP-ribose) Polymerase Inhibitors
- Poly(ADP-ribose) Polymerases -- genetics
- Temozolomide
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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