IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis. [electronic resource]
Producer: 20100820Description: 1274-85 p. digitalISSN:- 1538-8514
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Breast Neoplasms -- drug therapy
- Carcinoma -- drug therapy
- Caspases -- metabolism
- Drug Evaluation, Preclinical
- Drug Resistance, Neoplasm -- drug effects
- Drug Synergism
- Estradiol -- analogs & derivatives
- Female
- Fulvestrant
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Interferon Regulatory Factor-1 -- genetics
- Interferon-gamma -- pharmacology
- NF-kappa B -- genetics
- Proto-Oncogene Proteins c-bcl-2 -- genetics
- STAT1 Transcription Factor -- genetics
- Signal Transduction -- drug effects
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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