AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth. [electronic resource]
Producer: 20100820Description: 1100-10 p. digitalISSN:- 1538-8514
- Administration, Oral
- Animals
- Antineoplastic Agents -- administration & dosage
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Dose-Response Relationship, Drug
- Down-Regulation -- drug effects
- HCT116 Cells
- HT29 Cells
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Models, Biological
- Models, Molecular
- Neoplasms -- drug therapy
- Oncogene Protein v-akt -- antagonists & inhibitors
- Piperidines -- administration & dosage
- Protein Kinase Inhibitors -- administration & dosage
- Pyrazoles -- administration & dosage
- Ribosomal Protein S6 Kinases, 70-kDa -- antagonists & inhibitors
- Treatment Outcome
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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