Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032. [electronic resource]
Producer: 20100803Description: 39 p. digitalISSN:- 1479-5876
- Amino Acid Substitution -- genetics
- Animals
- Apoptosis -- drug effects
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Diagnostic Imaging
- Drug Resistance, Neoplasm -- drug effects
- Genome, Human -- genetics
- Humans
- Indoles -- pharmacology
- MAP Kinase Signaling System -- drug effects
- Melanoma -- enzymology
- Mice
- Mutation -- genetics
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphorylation -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- Proto-Oncogene Proteins c-akt -- metabolism
- Sulfonamides -- pharmacology
- Vemurafenib
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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