Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway. [electronic resource]
Producer: 20100903Description: 685-93 p. digitalISSN:- 1878-1705
- Acrolein -- toxicity
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- therapeutic use
- ErbB Receptors -- analysis
- Extracellular Signal-Regulated MAP Kinases -- analysis
- GTP Phosphohydrolases -- analysis
- Goblet Cells -- drug effects
- Humans
- Hyperplasia -- drug therapy
- Lung -- drug effects
- Male
- Mevalonic Acid -- therapeutic use
- Mucin 5AC -- antagonists & inhibitors
- Phosphorylation -- drug effects
- Pneumonia -- chemically induced
- Prenylation -- drug effects
- Rats
- Rats, Sprague-Dawley
- Simvastatin -- therapeutic use
- ras Proteins -- analysis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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