The structurally novel Ca2+ channel blocker Ro 40-5967, which binds to the [3H] desmethoxyverapamil receptor, is devoid of the negative inotropic effects of verapamil in normal and failing rat hearts. [electronic resource]
Producer: 19910425Description: 731-6 p. digitalISSN:- 0920-3206
- Animals
- Benzimidazoles -- metabolism
- Calcium Channel Blockers -- metabolism
- Calcium Channels
- Coronary Circulation -- drug effects
- Depression, Chemical
- Dose-Response Relationship, Drug
- Female
- Heart -- drug effects
- Heart Failure -- drug therapy
- Hemodynamics -- drug effects
- Male
- Mibefradil
- Myocardial Contraction -- drug effects
- Myocardial Infarction -- drug therapy
- Rats
- Rats, Inbred WKY
- Receptors, Nicotinic -- metabolism
- Tetrahydronaphthalenes -- metabolism
- Tritium
- Verapamil -- pharmacology
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Publication Type: Comparative Study; Journal Article
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