IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun. [electronic resource]
Producer: 20100719Description: 248-59 p. digitalISSN:- 1097-4644
- Cell Line
- Curcumin -- pharmacology
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Gene Expression Regulation, Enzymologic -- drug effects
- Glucose -- pharmacology
- Humans
- Interleukin-6 -- pharmacology
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Lipopolysaccharides -- pharmacology
- MAP Kinase Signaling System -- drug effects
- Matrix Metalloproteinase 1 -- genetics
- Mitogen-Activated Protein Kinase 1 -- metabolism
- Mitogen-Activated Protein Kinase 3 -- metabolism
- Monocytes -- drug effects
- Phagocytes -- drug effects
- Proto-Oncogene Proteins c-jun -- metabolism
- Simvastatin -- pharmacology
- Tissue Inhibitor of Metalloproteinases -- genetics
- Up-Regulation -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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