IL-1beta suppresses the formation of osteoclasts by increasing OPG production via an autocrine mechanism involving celecoxib-related prostaglandins in chondrocytes. [electronic resource]
Producer: 20100525Description: 308596 p. digitalISSN:- 1466-1861
- Animals
- Autocrine Communication -- drug effects
- Base Sequence
- Celecoxib
- Cell Differentiation -- drug effects
- Cell Line
- Cells, Cultured
- Chondrocytes -- cytology
- Culture Media, Conditioned
- DNA Primers -- genetics
- Dinoprostone -- metabolism
- Gene Expression -- drug effects
- Humans
- Inflammation Mediators -- metabolism
- Interleukin-1beta -- pharmacology
- Macrophage Colony-Stimulating Factor -- biosynthesis
- Mice
- Osteoclasts -- cytology
- Osteoprotegerin -- biosynthesis
- Prostaglandins -- metabolism
- Pyrazoles -- pharmacology
- RANK Ligand -- biosynthesis
- Sulfonamides -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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