Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). [electronic resource]
Producer: 20100705Description: 2321-5 p. digitalISSN:- 1464-3405
- Adenosine Triphosphate -- metabolism
- Animals
- Antineoplastic Agents -- chemistry
- Benzofurans -- chemistry
- Crystallography, X-Ray
- Humans
- Inhibitory Concentration 50
- Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors
- Mice
- Mice, Nude
- Microsomes -- metabolism
- Models, Molecular
- Neoplasms -- drug therapy
- Phosphatidylinositol 3-Kinases -- chemistry
- Protein Kinase Inhibitors -- chemistry
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Structure-Activity Relationship
- TOR Serine-Threonine Kinases
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Publication Type: Journal Article
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