Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway. [electronic resource]
Producer: 20100408Description: 1951-9 p. digitalISSN:- 1538-7445
- Angiogenesis Inhibitors -- pharmacology
- Animals
- Apoptosis -- drug effects
- Cell Growth Processes -- drug effects
- Cell Line, Tumor
- Chemotaxis -- drug effects
- Endothelial Cells -- cytology
- Humans
- Intracellular Signaling Peptides and Proteins -- metabolism
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Neovascularization, Pathologic -- drug therapy
- Pentacyclic Triterpenes
- Prostatic Neoplasms -- blood supply
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Ribosomal Protein S6 Kinases, 70-kDa -- antagonists & inhibitors
- Specific Pathogen-Free Organisms
- TOR Serine-Threonine Kinases
- Triterpenes -- pharmacology
- Vascular Endothelial Growth Factor A -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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