Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells. [electronic resource]
Producer: 20101207Description: 782-8 p. digitalISSN:- 1618-095X
- Apoptosis -- drug effects
- Caspase 3 -- metabolism
- Caspase 7 -- metabolism
- Chamaecyparis -- chemistry
- Diterpenes -- isolation & purification
- Electrophoresis, Polyacrylamide Gel
- Enzyme Activation
- HL-60 Cells
- Humans
- Magnetic Resonance Spectroscopy
- Phosphoprotein Phosphatases -- metabolism
- Phosphorylation
- Protein Phosphatase 2C
- Spectrometry, Mass, Electrospray Ionization
- Spectrophotometry, Ultraviolet
- bcl-Associated Death Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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