A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. [electronic resource]
Producer: 20100603Description: 735-42 p. digitalISSN:- 1532-6535
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- drug effects
- Adult
- Anti-HIV Agents -- pharmacology
- Area Under Curve
- Cytochrome P-450 Enzyme System -- drug effects
- Drug Combinations
- Drug Interactions
- Enzyme Induction -- drug effects
- Enzyme Inhibitors -- pharmacology
- Female
- Genotype
- HIV Protease Inhibitors -- pharmacology
- Humans
- Intestinal Mucosa -- metabolism
- Liver -- metabolism
- Male
- Pharmaceutical Preparations -- administration & dosage
- Phenotype
- Polymorphism, Single Nucleotide
- Pyridines -- pharmacology
- Pyrones -- pharmacology
- Ritonavir -- pharmacology
- Sulfonamides
- Young Adult
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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