Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury. [electronic resource]
Producer: 20100426Description: 46-52 p. digitalISSN:- 1521-0669
- Amino Acid Substitution
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Asparaginase -- therapeutic use
- Child
- Cytarabine -- therapeutic use
- Daunorubicin -- therapeutic use
- Endothelium, Vascular -- drug effects
- Epilepsy, Tonic-Clonic -- chemically induced
- Genetic Predisposition to Disease
- Humans
- Hyperhomocysteinemia -- complications
- Injections, Spinal
- Leukoencephalopathies -- chemically induced
- Male
- Methotrexate -- administration & dosage
- Methylenetetrahydrofolate Reductase (NADPH2) -- genetics
- Polymorphism, Single Nucleotide
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma -- complications
- Prednisone -- therapeutic use
- Remission Induction
- Sinus Thrombosis, Intracranial -- chemically induced
- Vincristine -- therapeutic use
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Publication Type: Case Reports; Journal Article
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