Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway. [electronic resource]
Producer: 20100506Description: 294-305 p. digitalISSN:- 1941-3297
- Analysis of Variance
- Animals
- Apoptosis -- drug effects
- Blood Flow Velocity
- Blotting, Western
- Carrier Proteins -- metabolism
- Cells, Cultured
- Chromones -- pharmacology
- Diabetes Mellitus, Experimental -- complications
- Diastole
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Fibrosis -- prevention & control
- Heart Failure -- etiology
- Immunohistochemistry
- Mice
- Microfilament Proteins
- Morpholines -- pharmacology
- Oxidative Stress
- Proto-Oncogene Proteins c-pim-1 -- metabolism
- Random Allocation
- Reverse Transcriptase Polymerase Chain Reaction
- STAT3 Transcription Factor -- metabolism
- Signal Transduction
- Thiamine -- analogs & derivatives
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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