Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice. [electronic resource]
Producer: 20100709Description: 856-71 p. digitalISSN:- 1476-5381
- Adenocarcinoma -- blood supply
- Animals
- Anticarcinogenic Agents -- pharmacology
- Antineoplastic Agents, Phytogenic -- pharmacology
- Antioxidants -- pharmacology
- Apoptosis -- drug effects
- Breast Neoplasms -- blood supply
- Caspases -- metabolism
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
- Cyclooxygenase 2 -- metabolism
- Dose-Response Relationship, Drug
- Female
- Humans
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Lactones -- pharmacology
- Lung Neoplasms -- metabolism
- Matrix Metalloproteinase 9 -- metabolism
- Mice
- Mice, Inbred BALB C
- NF-kappa B -- metabolism
- Neoplasm Invasiveness
- Paclitaxel -- pharmacology
- Reactive Oxygen Species -- metabolism
- Sesquiterpenes -- pharmacology
- Time Factors
- Tumor Burden
- Tumor Necrosis Factor-alpha -- metabolism
- Vascular Endothelial Growth Factor A -- metabolism
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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