Therapy of B-cell malignancies by anti-HLA-DR humanized monoclonal antibody, IMMU-114, is mediated through hyperactivation of ERK and JNK MAP kinase signaling pathways. [electronic resource]
Producer: 20100709Description: 5180-90 p. digitalISSN:- 1528-0020
- Animals
- Antibodies, Monoclonal -- immunology
- Antigens, CD -- immunology
- B-Lymphocytes
- Cell Line, Tumor
- Cytotoxins -- immunology
- Drug Screening Assays, Antitumor
- Enzyme Activation -- drug effects
- Extracellular Signal-Regulated MAP Kinases -- immunology
- Female
- HLA-DR Antigens -- immunology
- Hematologic Neoplasms -- drug therapy
- Humans
- MAP Kinase Kinase 4 -- immunology
- MAP Kinase Signaling System -- drug effects
- Mice
- Mice, SCID
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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