The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change. [electronic resource]
Producer: 20100316Description: 1628-39 p. digitalISSN:- 1520-4995
- Animals
- Blotting, Western
- Calcium -- metabolism
- Cell Line
- Circular Dichroism
- Cyclic Nucleotide-Gated Cation Channels -- chemistry
- Electrophoresis, Polyacrylamide Gel
- Electrophysiology
- Escherichia coli -- genetics
- Fluorescent Antibody Technique
- Humans
- Mice
- Microscopy, Confocal
- Models, Biological
- Mutation -- genetics
- Protein Stability
- Protein Structure, Secondary
- Recombinant Proteins -- chemistry
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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