G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling. [electronic resource]
Producer: 20100201Description: 340-3 p. digitalISSN:- 1095-9203
- Animals
- Binding Sites
- Blood Platelets -- physiology
- Clot Retraction
- Fibrinogen -- metabolism
- GTP-Binding Protein alpha Subunits, G12-G13 -- genetics
- Humans
- Integrin beta3 -- metabolism
- Ligands
- Mice
- Mice, Inbred C57BL
- Phosphorylation
- Platelet Adhesiveness
- Platelet Glycoprotein GPIIb-IIIa Complex -- metabolism
- Protein Binding
- Protein Structure, Tertiary
- Proto-Oncogene Proteins pp60(c-src) -- metabolism
- RNA, Small Interfering
- Recombinant Fusion Proteins -- metabolism
- Signal Transduction
- rhoA GTP-Binding Protein -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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