Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer. [electronic resource]
Producer: 20100309Description: 632-8 p. digitalISSN:- 1538-7445
- Apoptosis -- drug effects
- Basic Helix-Loop-Helix Transcription Factors -- biosynthesis
- Binding Sites
- Calcium-Binding Proteins -- metabolism
- Cell Cycle Proteins -- biosynthesis
- Cell Growth Processes -- physiology
- Drug Delivery Systems
- Epidermal Growth Factor -- genetics
- HeLa Cells
- Humans
- Immunoglobulin Fc Fragments -- genetics
- Intercellular Signaling Peptides and Proteins -- metabolism
- Jagged-1 Protein
- Ligands
- Lung Neoplasms -- drug therapy
- Membrane Proteins -- metabolism
- Peptide Fragments -- genetics
- Peptide Library
- Protein Structure, Tertiary
- Receptor, Notch3
- Receptors, Notch -- antagonists & inhibitors
- Recombinant Fusion Proteins -- genetics
- Serrate-Jagged Proteins
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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