SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition. [electronic resource]
Producer: 20100423Description: 1702-16 p. digitalISSN:- 1476-5594
- Anthracenes -- pharmacology
- Aurora Kinases
- Blotting, Western
- CDC2 Protein Kinase -- antagonists & inhibitors
- Cell Cycle Proteins -- metabolism
- Cell Line, Tumor
- Cyclin B -- metabolism
- Cyclin-Dependent Kinase 2 -- metabolism
- DNA Replication -- drug effects
- Enzyme Activation -- drug effects
- Flow Cytometry
- G2 Phase -- drug effects
- HCT116 Cells
- Humans
- JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Mitosis -- drug effects
- Phosphorylation -- drug effects
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins -- metabolism
- RNA Interference
- Tumor Suppressor Protein p53 -- metabolism
- Polo-Like Kinase 1
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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