Down-regulation of Notch-1 and Jagged-1 inhibits prostate cancer cell growth, migration and invasion, and induces apoptosis via inactivation of Akt, mTOR, and NF-kappaB signaling pathways. [electronic resource]
Producer: 20100812Description: 726-36 p. digitalISSN:- 1097-4644
- Apoptosis
- Calcium-Binding Proteins -- genetics
- Cell Line, Tumor
- Cell Movement
- Cell Proliferation
- Down-Regulation -- genetics
- Humans
- Intercellular Signaling Peptides and Proteins -- genetics
- Intracellular Signaling Peptides and Proteins -- metabolism
- Jagged-1 Protein
- Male
- Membrane Proteins -- genetics
- NF-kappa B -- metabolism
- Neoplasm Invasiveness
- Prostatic Neoplasms -- pathology
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Receptor, Notch1 -- genetics
- Serrate-Jagged Proteins
- Signal Transduction -- physiology
- TOR Serine-Threonine Kinases
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Retracted Publication
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