A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate. [electronic resource]
Producer: 20100209Description: 104-14 p. digitalISSN:- 1532-1827
- Adenocarcinoma -- drug therapy
- Animals
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Cell Line, Tumor -- drug effects
- Drug Delivery Systems
- Drug Design
- Enzyme Activation -- drug effects
- Female
- Humans
- Inositol Phosphates -- chemical synthesis
- Intracellular Signaling Peptides and Proteins -- drug effects
- Male
- Mice
- Mice, Nude
- Molecular Structure
- Ovarian Neoplasms -- drug therapy
- Phosphoinositide-3 Kinase Inhibitors
- Prostatic Neoplasms -- drug therapy
- Protein Kinase Inhibitors -- chemical synthesis
- Protein Serine-Threonine Kinases -- drug effects
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Structure-Activity Relationship
- TOR Serine-Threonine Kinases
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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