Conjugates of desferrioxamine B (DFOB) with derivatives of adamantane or with orally available chelators as potential agents for treating iron overload. [electronic resource]
Producer: 20100312Description: 1370-82 p. digitalISSN:- 1520-4804
- Adamantane -- chemistry
- Administration, Oral
- Animals
- Binding Sites
- Carboxylic Acids -- chemistry
- Cell Proliferation -- drug effects
- Cells, Cultured
- Chelating Agents -- chemistry
- Chromatography, High Pressure Liquid
- Crystallography, X-Ray
- Deferoxamine -- chemistry
- Dogs
- Ferric Compounds -- chemistry
- Humans
- Inhibitory Concentration 50
- Iron -- metabolism
- Iron Chelating Agents -- chemical synthesis
- Iron Overload -- drug therapy
- Kidney -- cytology
- Models, Molecular
- Molecular Structure
- Neuroectodermal Tumors, Primitive, Peripheral -- drug therapy
- Spectrometry, Mass, Electrospray Ionization
- Structure-Activity Relationship
- Transferrin -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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