A tolC mutant of Francisella tularensis is hypercytotoxic compared to the wild type and elicits increased proinflammatory responses from host cells. [electronic resource]
Producer: 20100326Description: 1022-31 p. digitalISSN:- 1098-5522
- Animals
- Bacterial Outer Membrane Proteins -- genetics
- Cell Line
- Colony Count, Microbial
- Endothelial Cells -- immunology
- Francisella tularensis -- immunology
- Gene Deletion
- Humans
- Inflammation
- Inflammation Mediators -- metabolism
- Liver -- microbiology
- Lung -- microbiology
- Macrophages -- immunology
- Mice
- Spleen -- microbiology
- Tularemia -- microbiology
- Virulence Factors -- deficiency
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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