Hypoxia-targeting by tirapazamine (TPZ) induces preferential growth inhibition of nasopharyngeal carcinoma cells with Chk1/2 activation. [electronic resource]
Producer: 20110906Description: 401-10 p. digitalISSN:- 1573-0646
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Carcinoma
- Cell Hypoxia -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Checkpoint Kinase 1
- Checkpoint Kinase 2
- Drug Screening Assays, Antitumor
- Enzyme Activation -- drug effects
- Gene Expression Regulation, Neoplastic -- drug effects
- Genome, Viral -- genetics
- Herpesvirus 4, Human -- genetics
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- antagonists & inhibitors
- Nasopharyngeal Carcinoma
- Nasopharyngeal Neoplasms -- enzymology
- Poly(ADP-ribose) Polymerases -- metabolism
- Protein Kinases -- metabolism
- Protein Serine-Threonine Kinases -- metabolism
- S Phase -- drug effects
- Signal Transduction -- drug effects
- Tirapazamine
- Triazines -- pharmacology
- Up-Regulation -- drug effects
- Viral Matrix Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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