In vitro-in vivo extrapolation of zolpidem as a perpetrator of metabolic interactions involving CYP3A. [electronic resource]
Producer: 20100506Description: 275-83 p. digitalISSN:- 1432-1041
- Administration, Oral
- Age Factors
- Aged
- Aged, 80 and over
- Area Under Curve
- Computer Simulation
- Cytochrome P-450 CYP3A -- metabolism
- Cytochrome P-450 CYP3A Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- metabolism
- Dose-Response Relationship, Drug
- Drug Interactions
- Enzyme Inhibitors -- pharmacology
- Female
- Humans
- Liver -- drug effects
- Male
- Metabolic Clearance Rate
- Microsomes, Liver -- enzymology
- Midazolam -- administration & dosage
- Models, Biological
- Pyridines -- pharmacology
- Recombinant Proteins -- antagonists & inhibitors
- Young Adult
- Zolpidem
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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