Chronic treatment with escitalopram but not R-citalopram translocates Galpha(s) from lipid raft domains and potentiates adenylyl cyclase: a 5-hydroxytryptamine transporter-independent action of this antidepressant compound. [electronic resource]
Producer: 20100413Description: 977-84 p. digitalISSN:- 1521-0103
- Adenylyl Cyclases -- metabolism
- Animals
- Antidepressive Agents -- chemistry
- Cell Line, Tumor
- Citalopram -- chemistry
- Colforsin -- pharmacology
- Cyclic AMP -- biosynthesis
- Enzyme Activation
- GTP-Binding Protein alpha Subunits, Gs -- metabolism
- Isoproterenol -- pharmacology
- Membrane Microdomains -- metabolism
- Protein Transport
- Rats
- Serotonin Plasma Membrane Transport Proteins -- physiology
- Selective Serotonin Reuptake Inhibitors -- chemistry
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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