Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. [electronic resource]
Producer: 20100222Description: 2351-60 p. digitalISSN:- 1083-351X
- Adenosine Triphosphate -- metabolism
- Antineoplastic Agents, Phytogenic -- pharmacology
- Binding Sites
- Camptothecin -- pharmacology
- Cell Survival -- drug effects
- Circular Dichroism
- DNA Ligase ATP
- DNA Ligases -- antagonists & inhibitors
- DNA Polymerase beta -- antagonists & inhibitors
- DNA Repair -- drug effects
- DNA Repair Enzymes -- antagonists & inhibitors
- Drug Resistance, Neoplasm -- drug effects
- Enzyme Inhibitors -- pharmacology
- Etoposide -- pharmacology
- Fluorescence Resonance Energy Transfer
- Humans
- Lung Neoplasms -- drug therapy
- Mutagenesis, Site-Directed
- Phosphotransferases (Alcohol Group Acceptor) -- antagonists & inhibitors
- Photoelectron Spectroscopy
- Piperidines -- pharmacology
- Poly-ADP-Ribose Binding Proteins
- Protein Conformation
- Pyrroles -- chemistry
- Radiation-Sensitizing Agents -- pharmacology
- Tumor Cells, Cultured
- Xenopus Proteins
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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