Acquired activation of the Akt/cyclooxygenase-2/Mcl-1 pathway renders lung cancer cells resistant to apoptosis. [electronic resource]
Producer: 20100319Description: 416-23 p. digitalISSN:- 1521-0111
- Animals
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cyclooxygenase 2 -- metabolism
- Doxorubicin -- pharmacology
- Drug Resistance, Neoplasm -- physiology
- Enzyme Activation -- physiology
- Humans
- Lung Neoplasms -- enzymology
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Myeloid Cell Leukemia Sequence 1 Protein
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Signal Transduction -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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