PPARgamma ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells. [electronic resource]
Producer: 20101021Description: 1347-57 p. digitalISSN:- 1582-4934
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors -- metabolism
- Blotting, Western
- Caco-2 Cells
- Colonic Neoplasms -- enzymology
- DNA, Neoplasm -- metabolism
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Ligands
- PPAR gamma -- metabolism
- Promoter Regions, Genetic -- genetics
- Prostaglandin D2 -- analogs & derivatives
- Protein Binding -- drug effects
- Proto-Oncogene Proteins c-myc -- metabolism
- RNA, Messenger -- genetics
- Repressor Proteins -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Rosiglitazone
- Telomerase -- antagonists & inhibitors
- Thiazolidinediones -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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