Zinc mesoporphyrin induces rapid proteasomal degradation of hepatitis C nonstructural 5A protein in human hepatoma cells. [electronic resource]
Producer: 20100507Description: 1909-19 p. digitalISSN:- 1528-0012
- Antiviral Agents -- pharmacology
- Carcinoma, Hepatocellular -- genetics
- Cell Line, Tumor
- Cysteine Proteinase Inhibitors -- pharmacology
- Dose-Response Relationship, Drug
- Down-Regulation
- Half-Life
- Hepacivirus -- drug effects
- Humans
- Leupeptins -- pharmacology
- Liver Neoplasms -- genetics
- Metalloporphyrins -- pharmacology
- Oligopeptides -- pharmacology
- Proteasome Endopeptidase Complex -- drug effects
- Protein Processing, Post-Translational -- drug effects
- Protein Stability
- RNA, Viral -- biosynthesis
- Time Factors
- Transfection
- Ubiquitination
- Viral Nonstructural Proteins -- genetics
- Virus Replication -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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