Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. [electronic resource]
Producer: 20100126Description: 1283-95 p. digitalISSN:- 1083-351X
- Animals
- Cartilage -- metabolism
- Cells, Cultured
- Cellular Senescence -- genetics
- Chondrocytes -- metabolism
- Cysteine Proteinase Inhibitors -- genetics
- Enzyme Activation -- genetics
- Gamma Rays -- adverse effects
- Humans
- Joint Diseases -- genetics
- Leupeptins -- pharmacology
- MAP Kinase Kinase 4 -- genetics
- MAP Kinase Signaling System -- genetics
- Proteasome Endopeptidase Complex -- genetics
- Proteasome Inhibitors
- Rabbits
- Reactive Oxygen Species -- metabolism
- Sirtuin 1 -- genetics
- Up-Regulation -- genetics
- p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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