Pressure-mediated hypertrophy and mechanical stretch induces IL-1 release and subsequent IGF-1 generation to maintain compensative hypertrophy by affecting Akt and JNK pathways. [electronic resource]
Producer: 20091217Description: 1149-58 p. digitalISSN:- 1524-4571
- Animals
- Apoptosis -- physiology
- Endomyocardial Fibrosis -- metabolism
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Hypertrophy, Left Ventricular -- metabolism
- Insulin-Like Growth Factor I -- metabolism
- Interleukin-1beta -- genetics
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Janus Kinase 2 -- metabolism
- Mice
- Mice, Mutant Strains
- Myocytes, Cardiac -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Reactive Oxygen Species -- metabolism
- Receptors, Interleukin-1 -- metabolism
- STAT5 Transcription Factor -- metabolism
- Signal Transduction -- physiology
- Stress, Mechanical
- Ventricular Pressure -- physiology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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