Structure-based virtual screening approach to the discovery of novel inhibitors of factor-inhibiting HIF-1: identification of new chelating groups for the active-site ferrous ion. [electronic resource]
Producer: 20100128Description: 7769-74 p. digitalISSN:- 1464-3391
- Algorithms
- Carboxylic Acids -- chemistry
- Catalytic Domain -- drug effects
- Chelating Agents -- pharmacology
- Computer Simulation
- Drug Evaluation, Preclinical
- Enzyme Inhibitors -- analysis
- Ferrous Compounds -- chemistry
- Ions
- Ligands
- Mixed Function Oxygenases
- Quinolines -- chemistry
- Repressor Proteins -- antagonists & inhibitors
- Structure-Activity Relationship
- Sulfonamides -- chemistry
- Triazoles -- chemistry
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Publication Type: Journal Article
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