CYP2C8 activity recovers within 96 hours after gemfibrozil dosing: estimation of CYP2C8 half-life using repaglinide as an in vivo probe. [electronic resource]
Producer: 20100126Description: 2359-66 p. digitalISSN:- 1521-009X
- Administration, Oral
- Area Under Curve
- Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors
- Biotransformation
- Blood Glucose -- drug effects
- Carbamates -- administration & dosage
- Cross-Over Studies
- Cytochrome P-450 CYP2C8
- Drug Interactions
- Enzyme Inhibitors -- administration & dosage
- Female
- Gemfibrozil -- administration & dosage
- Genotype
- Glucuronates -- blood
- Half-Life
- Humans
- Hypoglycemic Agents -- administration & dosage
- Hypolipidemic Agents -- administration & dosage
- Liver-Specific Organic Anion Transporter 1
- Male
- Models, Biological
- Molecular Probes -- administration & dosage
- Organic Anion Transporters -- genetics
- Phenotype
- Piperidines -- administration & dosage
- Young Adult
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
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