Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family. [electronic resource]
Producer: 20100909Description: G63-73 p. digitalISSN:- 1522-1547
- Acetophenones -- pharmacology
- Adenocarcinoma -- drug therapy
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Bcl-2-Like Protein 11
- Benzamides -- pharmacology
- Benzopyrans -- pharmacology
- Cell Line, Tumor
- Cytochromes c -- metabolism
- Disease Models, Animal
- Enzyme Inhibitors -- pharmacology
- Humans
- Membrane Proteins -- metabolism
- Mice
- Mice, Nude
- Mitochondria -- drug effects
- Neoplasm Transplantation
- Pancreatic Neoplasms -- drug therapy
- Protein Kinase C-delta -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Signal Transduction -- drug effects
- Tumor Suppressor Proteins -- metabolism
- Xenograft Model Antitumor Assays
- bcl-Associated Death Protein -- metabolism
- bcl-X Protein -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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