GHRH antagonist causes DNA damage leading to p21 mediated cell cycle arrest and apoptosis in human colon cancer cells. [electronic resource]
Producer: 20100114Description: 3149-56 p. digitalISSN:- 1551-4005
- Animals
- Apoptosis
- Caspase 3 -- metabolism
- Caspase 9 -- metabolism
- Cell Line, Tumor
- Colonic Neoplasms -- drug therapy
- Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
- DNA Damage
- DNA Fragmentation -- drug effects
- Growth Hormone-Releasing Hormone -- antagonists & inhibitors
- HCT116 Cells
- Humans
- Male
- Membrane Potential, Mitochondrial -- physiology
- Mice
- Mice, Nude
- Poly(ADP-ribose) Polymerases -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- S Phase
- Sermorelin -- analogs & derivatives
- Transplantation, Heterologous
- Tumor Suppressor Protein p53 -- metabolism
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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