Structure-activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase. [electronic resource]
Producer: 20091130Description: 5773-7 p. digitalISSN:- 1464-3405
- Allosteric Regulation
- Antiviral Agents -- chemical synthesis
- Drug Design
- Half-Life
- Hydrogen-Ion Concentration
- Hydrolysis
- Pyrazoles -- chemical synthesis
- RNA Helicases -- antagonists & inhibitors
- Serine Endopeptidases -- metabolism
- Serine Proteinase Inhibitors -- chemical synthesis
- Structure-Activity Relationship
- Viral Nonstructural Proteins -- antagonists & inhibitors
- West Nile Fever -- drug therapy
- West Nile virus -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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