In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis Dihydrofolate reductase, a potential target for anti-TB drug discovery. [electronic resource]
Producer: 20110228Description: 595-604 p. digitalISSN:- 1573-501X
- Amino Acid Sequence
- Antitubercular Agents -- chemistry
- Binding Sites
- Computational Biology -- methods
- Crystallography, X-Ray
- Drug Design
- Folic Acid Antagonists -- chemistry
- Humans
- Hydrogen Bonding -- drug effects
- Ligands
- Methotrexate -- chemistry
- Microbial Sensitivity Tests
- Molecular Dynamics Simulation
- Molecular Sequence Data
- Mycobacterium tuberculosis -- drug effects
- Ornithine -- analogs & derivatives
- Peptides -- chemistry
- Pterins -- chemistry
- Reproducibility of Results
- Substrate Specificity -- drug effects
- Tetrahydrofolate Dehydrogenase -- metabolism
- Triazines -- chemistry
- Tuberculosis -- drug therapy
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Publication Type: Journal Article
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