Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. [electronic resource]
Producer: 20091203Description: e1000559 p. digitalISSN:- 1553-7374
- Animals
- Apoptosis Regulatory Proteins -- immunology
- CARD Signaling Adaptor Proteins
- Calcium-Binding Proteins -- immunology
- Carrier Proteins -- immunology
- Caspase 1 -- immunology
- Cathepsin B -- metabolism
- Cytoskeletal Proteins -- immunology
- Disease Models, Animal
- Female
- HSP90 Heat-Shock Proteins -- metabolism
- Hemeproteins -- immunology
- Humans
- Inflammation -- immunology
- Interleukin-1beta -- biosynthesis
- Intracellular Signaling Peptides and Proteins -- metabolism
- Malaria -- immunology
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NLR Family, Pyrin Domain-Containing 3 Protein
- Neutrophil Infiltration -- immunology
- Phagocytosis
- Phosphorylation -- immunology
- Plasmodium chabaudi -- chemistry
- Potassium -- metabolism
- Protein-Tyrosine Kinases -- metabolism
- Proteomics
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- immunology
- Syk Kinase
- src-Family Kinases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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