Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. [electronic resource]
Producer: 20100201Description: 13-24 p. digitalISSN:- 1098-2744
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Cell Line, Tumor
- Cell Survival -- drug effects
- Curcumin -- pharmacology
- Dose-Response Relationship, Drug
- Down-Regulation -- drug effects
- Enzyme Activation -- drug effects
- Female
- Humans
- Inhibitor of Apoptosis Proteins
- Microtubule-Associated Proteins -- metabolism
- Oncogene Protein v-akt -- metabolism
- Ovarian Neoplasms -- genetics
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- RNA Interference
- Signal Transduction -- drug effects
- Spheroids, Cellular -- drug effects
- Survivin
- Time Factors
- Tumor Suppressor Protein p53 -- genetics
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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