Small molecule antagonists of Tcf4/beta-catenin complex inhibit the growth of HCC cells in vitro and in vivo. [electronic resource]
Producer: 20100422Description: 2426-36 p. digitalISSN:- 1097-0215
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors -- drug effects
- Blotting, Western
- Carcinoma, Hepatocellular -- drug therapy
- Cell Line, Tumor
- Cyclin D1 -- drug effects
- Dose-Response Relationship, Drug
- Down-Regulation -- drug effects
- Drug Screening Assays, Antitumor
- Gene Expression Regulation, Neoplastic -- drug effects
- Genes, myc -- drug effects
- Hepatocytes -- drug effects
- Humans
- Immunohistochemistry
- Inhibitor of Apoptosis Proteins
- Liver Neoplasms -- drug therapy
- Mice
- Mice, Nude
- Microtubule-Associated Proteins -- drug effects
- Perylene -- analogs & derivatives
- Pyrimidinones -- pharmacology
- Random Allocation
- Signal Transduction -- drug effects
- Survivin
- Transcription Factor 4
- Transcription Factors -- drug effects
- Triazines -- pharmacology
- Wnt Proteins -- metabolism
- Xenograft Model Antitumor Assays
- beta Catenin -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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