Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer. [electronic resource]
Producer: 20090915Description: 6396-404 p. digitalISSN:- 1538-7445
- ATP Binding Cassette Transporter, Subfamily B -- antagonists & inhibitors
- Animals
- Antibiotics, Antineoplastic -- pharmacology
- Breast Neoplasms -- drug therapy
- Disease Models, Animal
- Doxorubicin -- pharmacology
- Drug Resistance, Neoplasm -- genetics
- Female
- Gene Expression Regulation, Neoplastic -- physiology
- Genes, BRCA1
- Genes, p53
- Humans
- Mice
- Mice, Knockout
- Quinolines -- pharmacology
- Tumor Burden
- Up-Regulation -- physiology
- ATP-Binding Cassette Sub-Family B Member 4
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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