The transcriptional regulator Rv0485 modulates the expression of a pe and ppe gene pair and is required for Mycobacterium tuberculosis virulence. [electronic resource]
Producer: 20091013Description: 4654-67 p. digitalISSN:- 1098-5522
- Amino Acid Sequence
- Animal Structures -- microbiology
- Animals
- Antigens, Bacterial -- biosynthesis
- Bacterial Proteins -- biosynthesis
- Colony Count, Microbial
- DNA Transposable Elements
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Gene Knockout Techniques
- Lung -- pathology
- Mice
- Mice, Inbred BALB C
- Mice, SCID
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mycobacterium tuberculosis -- pathogenicity
- Oligonucleotide Array Sequence Analysis
- Reverse Transcriptase Polymerase Chain Reaction
- Sequence Alignment
- Survival Analysis
- Trans-Activators -- genetics
- Transcription Factors -- genetics
- Tuberculosis -- microbiology
- Virulence Factors -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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