Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-beta (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators. [electronic resource]
Producer: 20090929Description: 1784-95 p. digitalISSN:- 1471-4159
- Alanine -- metabolism
- Amyloid -- metabolism
- Amyloid beta-Peptides -- drug effects
- Animals
- Benzothiazoles
- Cells, Cultured
- Cerebral Cortex -- cytology
- Chelating Agents -- pharmacology
- Copper -- pharmacology
- Dose-Response Relationship, Drug
- Histidine -- metabolism
- Metallothionein 3
- Microscopy, Electron, Transmission -- methods
- Mutation
- Nerve Tissue Proteins -- pharmacology
- Neurons -- drug effects
- Peptide Fragments -- drug effects
- Rats
- Thiazoles
- Time Factors
- Zinc -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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