Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1alpha/VEGF signaling pathways in human breast cancer cells. [electronic resource]
Producer: 20091130Description: 90-103 p. digitalISSN:- 1097-0215
- Base Sequence
- Breast Neoplasms -- blood supply
- Cell Line, Tumor
- DNA Primers
- Diphosphonates -- pharmacology
- Enzyme-Linked Immunosorbent Assay
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism
- Immunohistochemistry
- Insulin-Like Growth Factor I -- physiology
- Neovascularization, Pathologic -- prevention & control
- Phosphatidylinositol 3-Kinases -- metabolism
- Protein Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction
- Signal Transduction -- physiology
- TOR Serine-Threonine Kinases
- Vascular Endothelial Growth Factor A -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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