Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms. [electronic resource]
Producer: 20090909Description: 11697-702 p. digitalISSN:- 1091-6490
- Animals
- Antineoplastic Agents, Alkylating -- therapeutic use
- Blotting, Western
- Cell Cycle Proteins -- metabolism
- DNA Damage
- Dacarbazine -- analogs & derivatives
- Enzyme Inhibitors -- pharmacology
- Flow Cytometry
- Fluorescent Antibody Technique
- Gene Expression Regulation, Enzymologic -- drug effects
- Glioblastoma -- drug therapy
- Mice
- Mice, SCID
- Neuroblastoma -- drug therapy
- Protein Phosphatase 2 -- antagonists & inhibitors
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Temozolomide
- Polo-Like Kinase 1
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Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
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