Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib. [electronic resource]
Producer: 20101021Description: 535-42 p. digitalISSN:- 1573-0646
- Annexin A5 -- metabolism
- Antineoplastic Agents -- pharmacology
- Benzenesulfonates -- pharmacology
- Cell Death -- drug effects
- Cell Line, Tumor
- Drug Synergism
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Female
- HIV Protease Inhibitors -- pharmacology
- Humans
- Membrane Potential, Mitochondrial -- drug effects
- Mitochondria -- drug effects
- Myeloid Cell Leukemia Sequence 1 Protein
- Nelfinavir -- pharmacology
- Niacinamide -- analogs & derivatives
- Ovarian Neoplasms -- enzymology
- Phenylurea Compounds
- Phosphorylation -- drug effects
- Propidium -- metabolism
- Protein Stability -- drug effects
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Pyridines -- pharmacology
- Sorafenib
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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