Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in mice. [electronic resource]
Producer: 20091224Description: 292-9 p. digitalISSN:- 1755-3245
- Animals
- Antigens, CD -- genetics
- Blood Pressure -- drug effects
- Cadherins -- genetics
- Cell Cycle Proteins
- Cells, Cultured
- Cloning, Molecular
- Dose-Response Relationship, Drug
- Down-Regulation
- Endothelial Cells -- drug effects
- Endothelin-1 -- blood
- Gene Expression Regulation, Enzymologic
- Genotype
- Humans
- Hypertension -- enzymology
- Intracellular Signaling Peptides and Proteins -- genetics
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Nerve Tissue Proteins -- genetics
- Nitric Oxide -- blood
- Nitric Oxide Synthase Type III -- genetics
- Phenotype
- Promoter Regions, Genetic
- RNA Interference
- RNA, Messenger -- metabolism
- Systole
- Tumor Suppressor Proteins
- Vasodilation -- drug effects
- Vasodilator Agents -- pharmacology
No physical items for this record
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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